Dr Alexander Greenhough

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About me

I recently joined UWE Bristol as a research-focused (50% research-time) Senior Lecturer and Principal Investigator in Biomedical Sciences.

I did my undergraduate degree at the University of Warwick, followed by a PhD with Prof Chris Paraskeva in the Cancer Research UK Colorectal Tumour Biology group at the University of Bristol. I went on to hold senior Cancer Research UK- and BBSRC-funded postdoctoral positions at the University of Bristol, where I retain an Honorary Senior Lectureship in the School of Cellular & Molecular Medicine and maintain active collaborations.   

My lab is based in the Centre for Research in Biosciences. We are interested in understanding the role of cell signalling in the tumour microenvironment during cancer development. We are using the latest tissue culture models of cancer (including 3D organoids) and omics technologies (transcriptomics and proteomics) coupled with bioinformatics to understand how hypoxia (reduced tissue oxygen levels) drives cancer development.

Since joining UWE in 2019, I have secured substantial funding from the Wellcome Trust and Bowel Cancer UK, along with a Vice-Chancellor's Early Career Researcher Award.

My recent work in the hypoxia field has attracted significant media attention that includes interviews for BBC Radio and comments in the Guardian.

For details of my publications, please visit Google Scholar or ORCID.

You can also follow me on Twitter.

I am always keen to hear from prospective PhD students. If you are interested in doing a PhD in my lab, please get in touch. 

Area of expertise

Cancer Biology, Tumour Microenvironment, Signal Transduction, Hypoxia, Autophagy, Drug Discovery, Bioinformatics.


Selected Awards
• 2019 Wellcome Trust Seed Award in Science: £100,000 (Principal Investigator, UWE)
• 2019 Bowel Cancer UK Pilot Grant: £25,000 (Principal Investigator, UWE)
• 2019 Vice Chancellor’s Early Career Researcher Award: £15,000 (Principal Investigator, UWE)
• 2019 Elizabeth Blackwell Institute Translational & Knowledge Transfer Award: £25,000 (co-I, UoB)
• 2017 Genetics Society Prize (Best Talk) Genes, Development & Disease Conference, University of Cardiff
• 2017 Academy of Medical Sciences Poster & Presentation Prize (Finalist) South-West Region
• 2016 BACR Prize Winner (Best Overall Presentation) at Cancer Therapy Conference, University of Bristol
• 2011 Cancer Research UK Programme Award in Science: £1,200,000 (Named Staff) University of Bristol

Publications

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