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- Qualifications:B.Sc. (Warwick), Ph.D. (Bristol)
- Position:Senior Lecturer in Biomedical Sciences
- Department:HAS - Applied Sciences
- Telephone:+4411732 86931
- Email:Alexander.Greenhough@uwe.ac.uk
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About me
I've recently joined UWE Bristol as a research-focused (≥50%) new blood senior lecturer and principal investigator, with major interests in cancer biology and the tumour microenvironment.
Following an undergraduate degree at the University of Warwick, I did my Ph.D. with Prof. Chris Paraskeva in the Cancer Research UK Colorectal Tumour Biology laboratory at the University of Bristol. I went on to hold senior Cancer Research UK- and BBSRC-funded postdoctoral positions at the University of Bristol, where I retain an honorary senior lectureship and maintain important collaborations.
My lab is interested in understanding the role of cell signalling in the tumour microenvironment during cancer development. We are using the latest tissue culture models of cancer (including 3D organoids) and omics technologies (transcriptomics and proteomics) coupled with bioinformatics to understand how hypoxia (reduced tissue oxygen levels) drives cancer development.
Recently awarded funding (as Principal Investigator):
- Wellcome Trust Seed Award in Science (~£100,000)
https://wellcome.ac.uk/funding/people-and-projects/grants-awarded/understanding-hypoxia-induced-signalling-mechanisms
- Bowel Cancer UK Pilot Grant (~£25,000)
https://www.bowelcanceruk.org.uk/research/our-research/current-research-projects/investigating-ways-to-improve-chemoradiotherapy-for-rectal-cancer-patients/
- Vice-Chancellor's Early Career Researcher Award (~£13,000)
Area of expertise
Cancer Biology, Tumour Microenvironment, Signal Transduction, Hypoxia, Autophagy, Apoptosis, Drug Discovery, Bioinformatics.
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