Dr Alexander Greenhough

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About me

In 2019 I joined the Faculty of Health and Applied Sciences as a research-focused Senior Lecturer and Principal Investigator in Biomedical Sciences (with 50% protected research time). Since joining UWE Bristol, I have won a Vice-Chancellor's Early Career Researcher Award and secured substantial external funding from Bowel Cancer UK and the Wellcome Trust.

I did my BSc at the University of Warwick, followed by a PhD with Prof Chris Paraskeva at the University of Bristol in the Cancer Research UK Colorectal Tumour Biology group. I went on to hold senior Cancer Research UK- and BBSRC-funded positions, and I retain an Honorary Senior Lectureship at the University of Bristol in the School of Cellular and Molecular Medicine, where I maintain active collaborations. My recent work on the role of hypoxia in cancer has attracted significant media attention that included interviews for BBC Radio and invited commentaries for the Guardian newspaper.

My lab is based in the Centre for Research in Biosciences (CRIB). We are using the latest tissue culture models of cancer (patient-derived 3D organoids) coupled to omics technologies (transcriptomics and proteomics) and bioinformatics to understand how microenvironmental factors regulate cell signalling to drive cancer development. As well as shedding light on fundamental cell biology, a goal of this research is to discover 'druggable' targets that could be used to develop new strategies to prevent and treat cancer. Ultimately, we aim to translate this knowledge into the clinic to improve outcomes for cancer patients.  

As well as being an active researcher, I am also passionate about learning and teaching in higher education. I lead a module on Cell Signalling for the BSc Biomedical Sciences programme, and teach related subjects at postgraduate level as well as for CPD.

For details of my publications, citations and funding visit Google Scholar or ORCID. You can also follow me on Twitter @alex_greenhough.

Area of expertise

***I currently have a BBSRC-funded 4-year PhD studentship available, for details visit https://bit.ly/3kau89M

Cancer Biology, Tumour Microenvironment, Signal Transduction, Hypoxia, Autophagy, Drug Discovery, Bioinformatics.
Selected Awards
• 2019 Wellcome Trust Seed Award in Science: £100,000 (Principal Investigator, UWE)
• 2019 Bowel Cancer UK Pilot Grant: £25,000 (Principal Investigator, UWE)
• 2019 Vice Chancellor’s Early Career Researcher Award: £15,000 (Principal Investigator, UWE)
• 2019 Elizabeth Blackwell Institute Translational & Knowledge Transfer Award: £25,000 (co-I, UoB)
• 2017 Genetics Society Prize (Best Talk) Genes, Development & Disease Conference, University of Cardiff
• 2017 Academy of Medical Sciences Poster & Presentation Prize (Finalist) South-West Region
• 2016 BACR Prize Winner (Best Overall Presentation) at Cancer Therapy Conference, University of Bristol
• 2011 Cancer Research UK Programme Award in Science: £1,200,000 (Named Staff) University of Bristol

Publications

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