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Department staff:
Collaborations:
- University of Bristol
- CRUK Beatson Institute
- University of Sussex
- University Hospitals Bristol
- University of Bath
Research staff:
Teaching staff:
- Qualifications:BSc (Warwick), PhD (Bristol), FHEA
- Position:Senior Lecturer in Biomedical Sciences
- Department:HAS - Applied Sciences
- Telephone:+4411732 86931
- Email:Alexander.Greenhough@uwe.ac.uk
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About me
In 2019 I joined the Faculty of Health and Applied Sciences as a research-focused Senior Lecturer and Principal Investigator in Biomedical Sciences (with 50% protected research time). Since joining UWE Bristol, I have won a Vice-Chancellor's Early Career Researcher Award and secured substantial external funding from Bowel Cancer UK and the Wellcome Trust.
I did my BSc at the University of Warwick, followed by a PhD with Prof Chris Paraskeva in the Cancer Research UK Colorectal Tumour Biology lab at the University of Bristol. I went on to hold senior CRUK- and BBSRC-funded positions at Bristol, and I retain an Honorary Senior Lectureship and maintain active collaborations.
My new lab is based in the Centre for Research in Biosciences (CRIB). We use tissue culture models of cancer (patient-derived 3D organoids) coupled to omics technologies (transcriptomics/proteomics) and bioinformatics to understand how microenvironmental factors regulate cell signalling to drive cancer development. As well as shedding light on fundamental cell biology, a goal of this research is to discover 'druggable' targets that could be used to develop new strategies to prevent and treat cancer. Ultimately, we aim to translate this knowledge into the clinic to improve outcomes for cancer patients.
My recent work on the role of hypoxia in cancer has attracted media attention that included interviews for BBC Radio and invited commentaries for the Guardian. For details of my publications, citations and funding visit Google Scholar and ORCID. Follow me on Twitter https://twitter.com/alex_greenhough.
Teaching: design, delivery and assessment of lectures and assessments for BSc and Masters level degrees in Biomedical Sciences (IBMS accredited), Healthcare Sciences, Biological Sciences as well as Genomics for Nurses and Healthcare Professionals.
Module lead for Cell Signalling (BMS).
Area of expertise
Cancer Biology, Tumour Microenvironment, Signal Transduction, Hypoxia, Autophagy, Drug Discovery, Bioinformatics.
Publications
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