Dr Alexander Greenhough

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About me

***I currently have a fully-funded UKRI BBSRC 4-year PhD studentship available—click for details***

In 2019 I joined the Faculty of Health and Applied Sciences as a research-focused Senior Lecturer and Principal Investigator in Biomedical Sciences (with 50% protected research time). Since joining UWE Bristol, I have won a Vice-Chancellor's Early Career Researcher Award and secured substantial external funding from Bowel Cancer UK and the Wellcome Trust.

I did my BSc at the University of Warwick, followed by a PhD with Prof Chris Paraskeva in the Cancer Research UK Colorectal Tumour Biology lab at the University of Bristol. I went on to hold senior CRUK- and BBSRC-funded positions at Bristol, and I retain an Honorary Senior Lectureship and maintain active collaborations.

My new lab is based in the Centre for Research in Biosciences (CRIB). We use tissue culture models of cancer (patient-derived 3D organoids) coupled to omics technologies (transcriptomics/proteomics) and bioinformatics to understand how microenvironmental factors regulate cell signalling to drive cancer development. As well as shedding light on fundamental cell biology, a goal of this research is to discover 'druggable' targets that could be used to develop new strategies to prevent and treat cancer. Ultimately, we aim to translate this knowledge into the clinic to improve outcomes for cancer patients.  

My recent work on the role of hypoxia in cancer has attracted media attention that included interviews for BBC Radio and invited commentaries for the Guardian. For details of my publications, citations and funding visit Google Scholar and ORCID. Follow me on Twitter https://twitter.com/alex_greenhough.


Area of expertise

***I currently have a fully-funded UKRI BBSRC 4-year PhD studentship available—click for details***

 This is a collaborative project between UWE and the University of Bristol. For details of the project please visit FindAPhD.com or click here. For details on eligibility and how to apply visit https://www.swbio.ac.uk/programme/how-to-apply/.

Cancer Biology, Tumour Microenvironment, Signal Transduction, Hypoxia, Autophagy, Drug Discovery, Bioinformatics.
Selected Awards
• 2019 Wellcome Trust Seed Award in Science: £100,000 (Principal Investigator, UWE)
• 2019 Bowel Cancer UK Pilot Grant: £25,000 (Principal Investigator, UWE)
• 2019 Vice Chancellor’s Early Career Researcher Award: £15,000 (Principal Investigator, UWE)
• 2019 Elizabeth Blackwell Institute Translational & Knowledge Transfer Award: £25,000 (co-I, UoB)
• 2017 Genetics Society Prize (Best Talk) Genes, Development & Disease Conference, University of Cardiff
• 2017 Academy of Medical Sciences Poster & Presentation Prize (Finalist) South-West Region
• 2016 BACR Prize Winner (Best Overall Presentation) at Cancer Therapy Conference, University of Bristol
• 2011 Cancer Research UK Programme Award in Science: £1,200,000 (Named Staff) University of Bristol

Publications

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