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- Qualifications:PhD
- Position:Research Fellow
- Telephone:+4411732 86186
- Email:Ibidapo.Williams@uwe.ac.uk
About me
I have a doctorate degree from De Montfort University where I studied Molecular toxicology. During my time at De Montfort University, I developed several expression DNAs, these plasmids were used to established expression systems both in mammalian and yeast cells. The expression systems were taken up for commercial research by a company, CYP Design LTD. Also during this time, I developed a crude technique for using whole cells in the biotransformation of natural compounds and other potential therapeutic target drugs. E.g Chrysin to Baiceilin etc. I was involved in the project of establishment of the point of care or home use bio-sensor for vitamin D using the whole cell's system.
Area of expertise
- Excellent background in molecular cloning techniques (DNA amplification and cloning, vector design, Ligation of insert + Vector, DNA sequence analysis, mutagenesis, gel purification, Electrophoresis, archiving of samples, sample preparation for transfections into a mammalian cell, and purity check). I have clone more than 40 plasmids that are have been expressed in mammalian and yeast cells.
- Development of Expression system used in Bio-sensor for home or point of care for patient use.
- Vast experience in primer design, vector modification, promoter modification, tandem for expression up-regulation, and PCR.
- The design of plasmid Maps constructs for protein expression.
- Expert in writing, criticizing both academic and industrial journals
- Actively collaboration with big pharma for drug discovery potential (Presently working on the finding of metabolites products from AZD2014 (AstraZeneca compound drug), also I have generated plasmids that are presently available for use (depends on interest).
- I have an excellent Team spirit and Train team members when needed
- Design of Experiment (DOE)
- Process Modelling. Monitoring & Statistical Data Analysis Using SAS-JMP 7.0, Molecular Devices
- Process optimization, scale-up, and validation Studies for Bio-manufacturing of phase I-II products, including Cell Therapeutics and Proteins and enzymes(Yeast-Microsomes)
- Freeze drying (Lyophilisation of enzymes) protein products, dissolution,
- Mammalian Cell Culture, Cell Transfection, and Microbial Fermentation
- Batch and Fed-Batch Stirred Tank Bioreactor Operation and Troubleshooting
- Membrane Filtration, PCR.
- Metabolites and Protein Analysis and Characterization using LC-MS-Mass Spec, HPLC-Agilent, SDS-PAGE, Coomassie and Silver Staining, Western Blot, ELISA. UV-Spec, TLC, Densitometry Analyses, etc.
- Excellent knowledge of Clone Manager Professional 9(for construction of plasmids), SQL, SPSS.
- Documentation system (Lab Notebooks, SOP, BPRs, Process Validation, QC, Technical Reports
- GMP, GLP and ISO Guidelines, BSL-2 and BSL-3 Training
- Using automated liquid machines and storages
Publications
